./python.exe -m timeit -s 'from fractions import Fraction; f = Fraction(3, 2)' 'isinstance(3, Fraction); isinstance(f, Fraction)'
from 12.3 usec/loop to 3.44 usec/loop and
  ./python.exe -m timeit -s 'from fractions import Fraction' 'Fraction(3, 2)'
from 48.8 usec to 23.6 usec by avoiding genexps and sets in __instancecheck__
and inlining the common case from __subclasscheck__.